After all these years, some of these kill me every single time. Among them are:
"Duff Gardens, HURRAH!"
"Sorry, NO Homers!"
"Oh, and it's raspberry!"
"I've got an idea! These wienies will give me the quick energy I need to escape!"
The bus full of violinists in "The Springfield Files"
"Lisa? Am I wearing pants?"
"Young lady, in this house we obey the Laws of Thermodynamics!!"
Stupid Sexy Flanders
Ned's mom: "We've tried nothin', and we're all out of ideas!"
"Don't you see? That would be taking the easy way out!"
"I agree!" (Pushes button, blinding flash)
"Professor P. J. Cornucopia's Fantastic Foodmagorium and Great American Steakery!"
"Ah wash mahself with a rag on a stick!"
...to name a few.